The giant low-density lipoproteins (LDL) accumulation in the multi-layer artery wall model

摘要

The mathematical, four-layer model of the LDL transport across the arterialwall including the sensitivity of the transport coefficients to the wall shearstress (WSS) is studied. In that model the advection-diffusion equations inporous media are used to determine the LDL concentration profiles in each layerof the arterial wall. We demonstrate the effect of the giant accumulation ofthe LDL in the intima layer. This property turns out to be an interplay betweenthe layered structure of the arterial wall and WSS sensitivity of theendothelium. Interestingly, we also show that the single-layer models with thesame WSS sensitivity mechanism and corresponding parameters, obscure theaccumulation phenomenon, which predicts the one order of magnitude larger LDLconcentration.